Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis
نویسندگان
چکیده
منابع مشابه
Molecular basis of the interaction between proapoptotic truncated BID (tBID) protein and mitochondrial carrier homologue 2 (MTCH2) protein: key players in mitochondrial death pathway.
The molecular basis of the interaction between mitochondrial carrier homologue 2 (MTCH2) and truncated BID (tBID) was characterized. These proteins participate in the apoptotic pathway, and the interaction between them may serve as a target for anticancer lead compounds. In response to apoptotic signals, MTCH2 recruits tBID to the mitochondria, where it activates apoptosis. A combination of pep...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2016
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2015.166